Oldest sister city in the U.S. revealed – Can you guess the answer with 2-Down?

As a detective trying to solve the mystery of the crossword clue “With 2-Down, the oldest sister city in the U.S.“, my first step was to focus on the phrase “sister city“. This set me on the path of researching which cities have official sister city relationships with others. I began to eliminate cities that I knew were founded more recently, such as Los Angeles or Chicago. Then, I came across a piece of information that helped to confirm my suspicions: Toledo, Spain, has a sister city relationship with Toledo, Ohio. This led me to think that Toledo, Ohio, might be the answer to the clue. After double-checking my research, I found that Toledo, Ohio, was indeed the oldest designated sister city in the United States, having formed a partnership with Toledo, Spain in 1931. By following my instincts and engaging in a thorough research process, I was able to confidently deduce that “Toledo” was the correct answer to this intriguing crossword clue.