The “E” of HOMES

The answer to the crossword question “The ‘E’ of HOMES is ERIE” refers to the five great lakes in North America. ‘HOMES‘ is an acronym that represents each of these great lakes: Huron, Ontario, Michigan, Erie, and Superior. In this context, ‘The “E” of HOMES is ERIE‘ means that the letter ‘E‘ in the word ‘HOMES‘ represents the name of Lake Erie, one of the five great lakes of North America. Therefore, the answer to this crossword question would be ‘Erie‘.