The crossword clue “Rx request is MED” is referring to a common abbreviation used in the medical field. The letters “Rx” stand for prescription, which means a doctor’s order for a medication. The word “request” in this context is indicating that someone is asking for a prescription to be filled. The answer to this crossword clue is simply “MED“, which is short for medication. Therefore, the full meaning of the clue is that someone is asking for a prescription for medication to be filled.