As a detective, the first step to solving the mystery of a crossword clue is to carefully analyze every element of the clue to gain insights into the solution. In this case, the clue “Removals of impurities, informally” suggests that the answer is a term that refers to the process of eliminating toxins or waste products from the body in a less formal way. With this in mind, the letter count for the answer “DETOXES” seems to fit perfectly with the available spaces in the crossword puzzle. Additionally, the term “detox” is very commonly used in modern conversation for the process of removing impurities from the body. It all adds up, and the answer is clear – “DETOXES” indeed matches the clues and fills the space perfectly. The final piece of the puzzle has fallen into place, and another mystery has been solved by a quick-thinking and observant detective.