Region

The clue given in the crossword puzzle is “Region is AREA“. Essentially, the answer to the crossword clue is the word “area“. In geography, a region refers to a specific area or part of the world that has certain similarities or characteristics that distinguish it from other areas. Therefore, the relationship between the words “region” and “area” makes sense because an area can be considered a region if it has unique features or characteristics. In conclusion, the answer to the crossword puzzle is the word “area“, which perfectly fits in the given crossword space and matches the clue “Region is AREA“.