The answer to the crossword question “Prefix with political” is SOCIO. A prefix is a group of letters added to the beginning of a word to form a new word with a different meaning. In this case, the prefix “socio” means “relating to society.” When added to the word “political,” it creates the word “sociopolitical,” which refers to the intersection of social and political issues. This term is often used to describe events or situations that involve both social and political factors, such as protests, elections, or policy debates. Therefore, the answer to the crossword question is SOCIO.