The answer to the crossword question “Org. overseeing Rx’s” is FDA, which stands for the Food and Drug Administration. This organization is responsible for regulating and supervising the safety and efficacy of food, drugs, medical devices, and other products in the United States. The FDA ensures that these products are safe for human consumption and use, and that they meet the necessary standards for quality and effectiveness. With its mission to protect public health, the FDA plays a crucial role in ensuring that Americans have access to safe and effective medications.