As a detective, I approached the crossword clue ‘Mother of Artemis’ with a keen eye for detail and a thorough knowledge of Greek mythology. First, I recalled that Artemis was the goddess of the hunt, as well as the moon and childbirth. Next, I drew upon my knowledge of her parentage, knowing that she was one of the children of Zeus and his mistress Leto. Therefore, I concluded that the answer to the clue must be Leto, the mother of Artemis, and her twin brother Apollo. It was a satisfying puzzle to solve, as I pieced together various clues and insights to come to the correct conclusion.