As soon as I saw the clue ‘Lead-in to tech‘, my mind immediately jumped to the prefix ‘bio‘ which means life or living organisms. While ‘tech’ seems to have a more modern connotation, it is often used in conjunction with the concept of bioengineering, biotechnology, and medical technology. From there, I started to think of other words that utilize the prefix ‘bio‘ such as ‘biodegradable‘ and ‘biology‘. The more plausible answer seemed to be ‘BIO‘ since it is a common abbreviation for ‘biography‘ and other terms related to the study of living organisms. I realized that this was the perfect fit as ‘BIO‘ is also commonly used as shorthand for ‘biotechnology‘ and ‘bioengineering‘ in scientific circles. Therefore, the answer ‘BIO‘ was the natural conclusion for this crossword clue, and one that I felt confident in sharing with others.