Lacking in vitality

The crossword clue “Lacking in vitality is ANEMIC” refers to the medical condition called anemia, which occurs when the body has a reduced number of red blood cells or hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen to the body’s tissues. When a person has anemia, their body may not receive sufficient oxygen, which can make them feel weak and fatigued. Thus, the answer to the crossword question is “ANEMIC“.