The answer to the crossword question “Intense suffering” is AGONY. This word is often used to describe a state of extreme physical or emotional pain, distress, or anguish. It can be caused by a variety of factors, such as illness, injury, loss, or trauma. AGONY is a powerful and evocative word that conveys the depth and intensity of human suffering. It is a fitting answer to this crossword question and a reminder of the challenges and hardships that we all face in life.