The answer to the crossword question “Face-off in a 2004 science fiction film is ALIENVSPREDATOR” refers to a movie that was released in 2004, which involved two iconic extraterrestrial species – the Alien and the Predator. The film, as suggested by its title, revolves around the epic face-off (battle) between these two alien beings. The premise of the movie is set in a remote location where a group of explorers discovers an ancient pyramid, which turns out to be a hunting ground for the predators, who have been training to fight the Aliens for centuries. When the Aliens begin to spread, the predators are sent to eliminate them, leading to a fierce battle between the two species. The movie was directed by Paul W. S. Anderson and features a cast of talented actors, including Sanaa Lathan and Lance Henriksen.