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The phrase “Challenge accepted!” is often used to express excitement and confidence in taking on a difficult task, and it is often associated with the popular television show, How I Met Your Mother. In the context of a crossword puzzle clue, the answer to the question “‘Challenge accepted!’ is ITSABET” likely refers to the fact that “itsabet” is a slang phrase that can be interpreted as “it’s a bet” or “it’s a sure thing.” Therefore, the answer to the question is likely “ITSABET,” as this is a word that sounds like “it’s a bet” and is often associated with accepting a challenge or making a wager.