The answer to the crossword question “Big nuisance is PAIN” is pretty straightforward – the word is simply “pain“. Pain can be described as a sensation that is uncomfortable or even unbearable, typically caused by injury or illness. Pain can be physical or emotional and can vary in intensity and duration. It can disrupt daily activities, decrease productivity, and cause frustration and stress. Dealing with pain can sometimes be challenging, but seeking medical attention and practicing self-care techniques like exercise, stretching, and mindfulness can help alleviate symptoms and improve overall well-being.